The evolution of RNAi as a defence against viruses and transposable elements
DJ Obbard, KHJ Gordon, AH Buck… - … Transactions of the …, 2009 - royalsocietypublishing.org
RNA interference (RNAi) is an important defence against viruses and transposable elements
(TEs). RNAi not only protects against viruses by degrading viral RNA, but hosts and viruses …
(TEs). RNAi not only protects against viruses by degrading viral RNA, but hosts and viruses …
The origin of RNA interference: Adaptive or neutral evolution?
The origin of RNA interference (RNAi) is usually explained by a defense-based hypothesis,
in which RNAi evolved as a defense against transposable elements (TEs) and RNA viruses …
in which RNAi evolved as a defense against transposable elements (TEs) and RNA viruses …
RNAi: a defensive RNA-silencing against viruses and transposable elements
N Buchon, C Vaury - Heredity, 2006 - nature.com
RNA silencing is a form of nucleic-acid-based immunity, targeting viruses and genomic
repeated sequences. First documented in plants and invertebrate animals, this host defence …
repeated sequences. First documented in plants and invertebrate animals, this host defence …
Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
RNA interference (RNAi)-related pathways target viruses and transposable element (TE)
transcripts in plants, fungi, and ecdysozoans (nematodes and arthropods), giving protection …
transcripts in plants, fungi, and ecdysozoans (nematodes and arthropods), giving protection …
[HTML][HTML] RNAi in the regulation of mammalian viral infections
KT Jeang - BMC biology, 2012 - Springer
Although RNA interference (RNAi) is known to play an important part in defense against
viruses of invertebrates, its contribution to mammalian anti-viral defense has been a matter …
viruses of invertebrates, its contribution to mammalian anti-viral defense has been a matter …
On the origin and functions of RNA-mediated silencing: from protists to man
H Cerutti, JA Casas-Mollano - Current genetics, 2006 - Springer
Double-stranded RNA has been shown to induce gene silencing in diverse eukaryotes and
by a variety of pathways. We have examined the taxonomic distribution and the phylogenetic …
by a variety of pathways. We have examined the taxonomic distribution and the phylogenetic …
RNAi: nature abhors a double-strand
G Hutvágner, PD Zamore - Current opinion in genetics & development, 2002 - Elsevier
In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded
RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA …
RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA …
Induction and suppression of RNA silencing: insights from viral infections
O Voinnet - Nature Reviews Genetics, 2005 - nature.com
In eukaryotes, small RNA molecules engage in sequence-specific interactions to inhibit
gene expression by RNA silencing. This process fulfils fundamental regulatory roles, as well …
gene expression by RNA silencing. This process fulfils fundamental regulatory roles, as well …
RNAi: an ever-growing puzzle
In recent years, sequence-specific gene silencing has been an area of increasing focus,
both because of its interesting biology and because of its power as an experimental tool. A …
both because of its interesting biology and because of its power as an experimental tool. A …
RNA interference: genetic wand and genetic watchdog.
JM Bosher, M Labouesse - Nature Cell Biology, 2000 - nature.com
In many species, introduction of double-stranded RNA (dsRNA) induces potent and specific
gene silencing, a phenomenon called RNA interference or RNAi. The apparently …
gene silencing, a phenomenon called RNA interference or RNAi. The apparently …