Expression of somatostatin and dopamine 2 receptors in neuroendocrine tumours and the potential role for new biotherapies

R Srirajaskanthan, J Watkins, L Marelli, K Khan… - …, 2009 - karger.com
Introduction: Somatostatin and dopamine receptors are both G-protein-coupled receptors.
Somatostatin receptor (SSTR) expression in neuroendocrine tumours has been well …

[PDF][PDF] The role of somatostatin and dopamine D2 receptors in endocrine tumors

F Gatto, LJ Hofland - Endocrine Related Cancer, 2011 - academia.edu
Somatostatin (SS) and dopamine (DA) receptors have been highlighted as two critical
regulators in the negative control of hormonal secretion in a wide group of human endocrine …

Somatostatin and dopamine receptor expression in neuroendocrine neoplasms: correlation of immunohistochemical findings with somatostatin receptor scintigraphy …

E Diakatou, KI Alexandraki, AV Tsolakis… - Clinical …, 2015 - Wiley Online Library
Context The expression of somatostatin (sstr1‐5) and dopamine (DR) receptors in
neuroendocrine neoplasms (NEN s) facilitates diagnosis by tumour visualization with …

Low somatostatin receptor subtype 2, but not dopamine receptor subtype 2 expression predicts the lack of biochemical response of somatotropinomas to treatment …

LEA Wildemberg, LV Neto, DF Costa… - Journal of …, 2013 - Springer
Objectives: To evaluate somatostatin receptor 2A (SSTR2A) and dopamine receptor 2 (DR2)
protein expression in somatotropinomas and to relate it to response to somatostatin …

[HTML][HTML] The clinical–molecular interface of somatostatin, dopamine and their receptors in pituitary pathophysiology

D Ferone, F Gatto, M Arvigo, E Resmini… - Journal of …, 2009 - jme.bioscientifica.com
The role of somatostatin and dopamine receptors as molecular targets for the treatment of
patients with pituitary adenomas is well established. Indeed, dopamine and somatostatin …

Somatostatin and dopamine receptor profile of gastroenteropancreatic neuroendocrine tumors: an immunohistochemical study

E Diakatou, G Kaltsas, M Tzivras, G Kanakis… - Endocrine …, 2011 - Springer
Somatostatin and its synthetic analogs act through five specific somatostatin receptors (sstr1–
5), found on the cell membrane of various tumors, including endocrine ones. Dopamine—a …

The analysis of quantitative expression of somatostatin and dopamine receptors in gastro-entero-pancreatic tumours opens new therapeutic strategies

D O'Toole, A Saveanu, A Couvelard… - European Journal of …, 2006 - academic.oup.com
Objective Somatostatin (sst) are present in the majority of gastro-entero-pancreatic (GEP)
tumours. Effects of somatostatin receptor (sst) analogues are partial and of limited duration …

Somatostatin receptor subtypes in human non-functioning neuroendocrine tumors and effects of somatostatin analogue SOM230 on cell proliferation in cell line NCI …

K Ono, T Suzuki, Y Miki, Y Taniyama… - Anticancer …, 2007 - ar.iiarjournals.org
Well-differentiated neuroendocrine tumors (NT) expresses somatostatin receptors (sstr). A
composition of sstr subtype determines biological behavior. We therefore evaluated their …

Somatostatin-dopamine chimeras: a novel approach to treatment of neuroendocrine tumors

MD Culler - Hormone and Metabolic Research, 2011 - thieme-connect.com
A combination of basic research observations concerning the interaction of somatostatin
(SST) and dopamine (DA) receptors, and clinical reports of enhanced efficacy of combined …

Expression of somatostatin receptors 1-5 and dopamine receptor 2 in lung carcinoids: implications for a therapeutic role

G Kanakis, L Grimelius, A Spathis, R Tringidou… - …, 2015 - karger.com
Objective: The expression of somatostatin receptors (SSTRs) and dopamine receptor 2
(DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and …