BACKGROUND: Solid organ transplant centers are increasingly using induction
immunosuppression strategies. Induction immunosuppression involves the use of intense …

The success of solid organ transplantation has been directly related to the development of
immunosuppressive drug therapies. Preconditioning or induction therapy was developed to …

Background. Induction agents have been shown to reduce the rate of acute rejection. They
have not been clearly shown to improve graft and patient survival. Methods. United Network …

Induction immunosuppression is intense, prophylactic therapy used at the time of
transplantation based on the empiric observation that more powerful immunosuppression is …

Remarkable progress is being made in the implementation of novel cell-based
immunotherapeutics in solid organ transplantation studies. It is hoped that these new …

The significant development of immunosuppressive drug therapies within the past 20 years
has had a major impact on the outcome of clinical solid organ transplantation, mainly by …

Induction therapy is a heterogeneous application of perioperative antibody therapy used in
combination with a base immuno-suppressive regimen in solid-organ transplantation. Its use …

Despite significant advances in the field of transplantation in the past two decades, current
clinically available therapeutic options for immunomodulation remain fairly limited. The …

Transplantation is the only cure for end-stage organ failure. Current immunosuppressive
drugs have two major limitations: 1) non antigen specificity, which increases the risk of …

Organ transplantation has become a standard life-saving therapy for many causes of end
stage organ failure. Although valuable, it remains hampered by the requirement for, and …