Wnt factors are involved in the regulation of all steps of cartilage development. The activity of
Wnt factors is generally regulated at the extracellular level by factors like the Dkk family …

Abstract Wnt inhibitory factor 1 (Wif‐1) is a secreted antagonist of Wnt signalling. We recently
demonstrated that this molecule is expressed predominantly in superficial layers of …

Endochondral skeletal development involves the condensation of mesenchymal cells, their
differentiation into chondrocytes, followed by chondrocyte maturation, hypertrophy, and …

The Wnt family of growth factors are important regulators of several developmental
processes including skeletogenesis. To further investigate the role of Wnts we analysed their …

Wnt signalling plays important roles in patterning and outgrowth of the vertebrate limb.
Different mutations in Wnt genes, their antagonists or (co-) receptors result in patterning and …

Proper longitudinal growth of long bones relies on the regulation of specific spatial patterns
of chondrocyte proliferation and differentiation. We have studied the roles of two members of …

Cartilage not only plays essential roles in skeletal development and growth during pre-and
postnatal stages but also serves to provide smooth movement of skeletons throughout life …

The Wnt signaling network regulates chondrocyte differentiation, proliferation, and
maturation during embryonic limb development. In this review, we summarize studies of Wnt …

Mouse and human genetic data suggests that Wnt5a is required for jaw development but the
specific role in facial skeletogenesis is unknown. We mapped expression of WNT5A in the …

Wnt signaling is intrinsically involved in diverse cellular activities during cell differentiation,
early embryonic development and organogenesis. Although much is known regarding the …