BACKGROUND: A TH1-specific transcription factor, T-box–containing protein expressed in T
cells (T-bet), controls the production of both TH1 and TH2 cytokines in TH cell differentiation …

BACKGROUND: Previous studies have shown that mice lacking T-bet, a critical transcription
factor for TH1 cell differentiation, spontaneously develop airway inflammation with intense …

■ Abstract Background: Allergic asthma is caused by aberrant helper T (TH) type 2 immune
responses in susceptible individuals, characterized by airway hyperresponsiveness, chronic …

Dysfunctional expression of T-bet, a transcription factor that is critical for IFN-γ production,
has been implicated in the development of asthma. To investigate in detail the mechanisms …

Type 2 helper T (Th2) cells, a type of CD4 T cell, trigger allergic inflammation and the
production of antibodies. Type 1 helper T (Th1) cells produce interferon-γ, which suppresses …

BACKGROUND: Regardless of TH1/TH2 theory, CD4+ T cells of patients with allergic
asthma, a typical TH2 disease, and those of healthy subjects expressed equivalent levels of …

BACKGROUND: The transcription factor T-bet mediates IFN-γ production by TH1 cells and
suppresses TH2 cytokine production when ectopically expressed in polarized murine TH2 …

T-bet is a novel transcription factor regulating lineage commitment of T helper (Th)
lymphocytes to a predominant Th1 phenotype. Previous studies on T-bet and asthma …

Allergic asthma frequently starts in childhood, and environmental factors such as viruses,
allergens and occupational exposure can regulate the evolution of the disease. The …

Th1 and Th2 cytokines secreted by polarized effector T cells play a pivotal role in the
development of autoimmune and allergic diseases. However, the genetic basis of cytokine …