Bioactive sphingolipids, such as ceramide, sphingosine and sphingosine-1-phosphate are
known bio-effector molecules which play important roles in various aspects of cancer …

Among the many processes regulating cell death, ceramide signaling is a vital component.
We previously determined that acid ceramidase (AC) is upregulated in 60% of primary …

Sphingolipid metabolism plays an important role in determining the fate of a cell. Among
several sphingolipid metabolites, ceramide is a key player in intracellular signal …

Increasingly recognized as bioactive molecules, sphingolipids have been studied in a
variety of disease models. The impact of sphingolipids on cancer research facilitated the …

Sphingolipid metabolism is known to play a role in cell death, survival, and therapy
resistance in cancer. Sphingolipids, particularly dihydroceramide and ceramide, are …

Background Sphingolipids have been shown to play a key part in cancer cell growth and
death and have increasingly become the subject of novel anti-cancer therapies. Acid …

Acid ceramidase (AC) is overexpressed in most prostate tumors and confers oncogenic
phenotypes to prostate cancer cells. AC modulates the cellular balance between ceramide …

Abstract Acid ceramidase (AC), EC 3.5. 1.23, a lysosomal enzyme, catalyzes the hydrolysis
of ceramide to constituent sphingoid base, sphingosine, and fatty acid. Because AC …

Acid ceramidase (AC) overexpression has been observed in prostate cancer cell lines and
primary tumors, and contributes to resistance to chemotherapy and radiation. The …

Acid ceramidase (AC) catalyzes the hydrolysis of ceramide into sphingosine, in turn a
substrate of sphingosine kinases that catalyze its conversion into the mitogenic sphingosine …