Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus

S Agger, F Lopez‐Gallego… - Molecular …, 2009 - Wiley Online Library
Fungi are a rich source of bioactive secondary metabolites, and mushroom‐forming fungi
(Agaricomycetes) are especially known for the synthesis of numerous bioactive and often …

Agrocybe aegerita Serves As a Gateway for Identifying Sesquiterpene Biosynthetic Enzymes in Higher Fungi

C Zhang, X Chen, A Orban, S Shukal, F Birk… - ACS Chemical …, 2020 - ACS Publications
Terpenoids constitute a structurally diverse group of natural products with wide applications
in the pharmaceutical, nutritional, flavor and fragrance industries. Fungi are known to …

Insight into metabolic diversity of the brown‐rot basidiomycete Postia placenta responsible for sesquiterpene biosynthesis: semi‐comprehensive screening of …

H Ichinose, T Kitaoka - Microbial biotechnology, 2018 - Wiley Online Library
A wide variety of sesquiterpenoids have been isolated from basidiomycetes, and their
bioactive properties have attracted significant attention in an effort to understand …

Traversing the fungal terpenome

MB Quin, CM Flynn, C Schmidt-Dannert - Natural product reports, 2014 - pubs.rsc.org
Covering: 1965–2014 Fungi (Ascomycota and Basidiomycota) are prolific producers of
structurally diverse terpenoid compounds. Classes of terpenoids identified in fungi include …

Selectivity of fungal sesquiterpene synthases: role of the active site's H-1α loop in catalysis

F López-Gallego, GT Wawrzyn… - Applied and …, 2010 - Am Soc Microbiol
Sesquiterpene synthases are responsible for the cyclization of farnesyl pyrophosphate into a
myriad of structurally diverse compounds with various biological activities. We examine here …

Mushroom hunting by using bioinformatics: application of a predictive framework facilitates the selective identification of sesquiterpene synthases in basidiomycota

MB Quin, CM Flynn, GT Wawrzyn, S Choudhary… - …, 2013 - Wiley Online Library
The Basidiomycota fungi represent a diverse source of natural products, particularly the
sesquiterpenoids. Recently, genome sequencing, genome mining, and the subsequent …

Three previously unrecognised classes of biosynthetic enzymes revealed during the production of xenovulene A

R Schor, C Schotte, D Wibberg, J Kalinowski… - Nature …, 2018 - nature.com
Xenovulene A is a complex fungal meroterpenoid, produced by the organism hitherto known
as Acremonium strictum IMI 501407, for which limited biosynthetic evidence exists. Here, we …

Discovery and characterization of terpenoid biosynthetic pathways of fungi

GT Wawrzyn, SE Bloch, C Schmidt-Dannert - Methods in enzymology, 2012 - Elsevier
Fungi produce a myriad of terpenoids with a broad range of biological activities, many of
which can be adapted to human use. This requires knowledge of the enzymes responsible …

Identification of Diterpene Biosynthetic Gene Clusters and Functional Analysis of Labdane-Related Diterpene Cyclases in Phomopsis amygdali

T Toyomasu, R Niida, H Kenmoku… - Bioscience …, 2008 - Taylor & Francis
Two diterpene biosynthesis gene clusters in the fusicoccin-producing fungus, Phomopsis
amygdali, were identified by genome walking from PaGGS1 and PaGGS4 which encode the …

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

HYY Yap, MJ Muria-Gonzalez, BH Kong… - Microbial Cell …, 2017 - Springer
Background Genome mining facilitated by heterologous systems is an emerging approach
to access the chemical diversity encoded in basidiomycete genomes. In this study, three …