HLA-DRB1⁎ 15 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis
K Imrell, E Greiner, J Hillert, T Masterman - Journal of neuroimmunology, 2009 - Elsevier
Abstract Carriage of HLA-DRB1⁎ 15 is the most important genetic risk factor in multiple
sclerosis (MS), while CSF-specific oligoclonal immunoglobulin G bands (OCB) constitute the …
sclerosis (MS), while CSF-specific oligoclonal immunoglobulin G bands (OCB) constitute the …
Association of HLA‐DRB1* 15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort
L Romero‐Pinel, S Martínez‐Yélamos… - European Journal of …, 2011 - Wiley Online Library
Background and objective: The HLA‐DRB1* 15 allele is consistently associated with
multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the …
multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the …
Associations of HLA DRB1 alleles with IgG oligoclonal bands and their influence on multiple sclerosis course and disability status
Background and aim: Oligoclonal bands (OCB) may be associated with the genes of HLA
complex, which allows to consider the possible interaction of genetic and immunological …
complex, which allows to consider the possible interaction of genetic and immunological …
Does the DRB1⁎ 1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients?: HLA in primary progressive multiple …
CCF Vasconcelos, O Fernández, L Leyva… - Journal of …, 2009 - Elsevier
The effect of HLA alleles on the outcome of multiple sclerosis (MS) has been widely
investigated; however, results are conflicting and no consistent correlation has been …
investigated; however, results are conflicting and no consistent correlation has been …
HLA‐DR15 is associated with lower age at onset in multiple sclerosis
T Masterman, A Ligers, T Olsson… - Annals of Neurology …, 2000 - Wiley Online Library
To date, more than a dozen studies have investigated the role of HLA genes in determining
clinical course and disease severity in multiple sclerosis (MS); in each of these studies …
clinical course and disease severity in multiple sclerosis (MS); in each of these studies …
The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population
AM Silva, C Pereira, A Bettencourt, C Carvalho… - Journal of the …, 2007 - Elsevier
BACKGROUND: The association between susceptibility to multiple sclerosis (MS) and HLA-
DRB1⁎ 15 has been reported in various European populations. OBJECTIVE: To investigate …
DRB1⁎ 15 has been reported in various European populations. OBJECTIVE: To investigate …
HLA-DRB1 and disease outcome in multiple sclerosis
SJM Weatherby, W Thomson, L Pepper, R Donn… - Journal of …, 2001 - Springer
The association between susceptibility to multiple sclerosis (MS) and the class II MHC allele
HLA-DRB1* 15 is well established although a possible relationship between this allele and …
HLA-DRB1* 15 is well established although a possible relationship between this allele and …
HLA‐DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population
L Romero‐Pinel, JM Pujal… - European Journal of …, 2011 - Wiley Online Library
Background and objective: The association of HLA‐DRB1* 15 with susceptibility to multiple
sclerosis (MS) has been consistently reported although its effect on the clinical phenotype is …
sclerosis (MS) has been consistently reported although its effect on the clinical phenotype is …
Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition
Background: HLA-DRB1* 1501 (DR15) and other HLA class II alleles increase the risk of
developing multiple sclerosis (MS). However, the contribution of genetic heterogeneity to the …
developing multiple sclerosis (MS). However, the contribution of genetic heterogeneity to the …
The impact of HLA‐A and‐DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients
C Smestad, B Brynedal, G Jonasdottir… - European journal of …, 2007 - Wiley Online Library
The human leucocyte antigen (HLA) class II haplotype DRB1* 15–DQB1* 06 (DR15–DQ6) is
associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS …
associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS …
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