Background Conventional compartmental pharmacokinetic models wrongly assume
instantaneous drug mixing in the central compartment, resulting in a flawed prediction of …

Background Target-controlled infusion is an increasingly common type of administration for
propofol. This method requires accurate knowledge of pharmacokinetics, including the …

Background Unresolved issues with propofol include whether the pharmacokinetics are
linear with dose, are influenced by method of administration (bolus vs. infusion), or are …

Background The relationship between patient characteristics and anesthesia induction dose
at a high administration rate is unclear. This study was designed to investigate the relation …

BACKGROUND: Pharmacokinetic (PK) models are used to predict drug concentrations for
infusion regimens for intraoperative displays and to calculate infusion rates in target …

Aim To analyze population pharmacokinetics of propofol in Chinese surgical patients using
a nonlinear mixed-effect model (NONMEM) program and to quantitate the effects of …

The recently introduced open-target-controlled infusion (TCI) systems can be programmed
with any pharmacokinetic model, and allow either plasma-or effect-site targeting. With effect …

Background The authors hypothesized a difference in plasma-effect site equilibration,
depicted by a first-order constant k (e0), depending on the injection rate of propofol. Methods …

BACKGROUND: With the growing use of pharmacokinetic (PK)-driven drug delivery and/or
drug advisory displays, identifying the PK model that best characterizes propofol plasma …

We compared the predictive performance of the existing Diprifusor and Schnider models,
used for target‐controlled infusion of propofol, with a new modification of the Diprifusor …