α‐Synuclein is an intrinsically unfolded protein that can adopt a partially helical structure
when it interacts with different lipid membranes. Its pathological relevance is linked to its …

Abstract α-Synuclein is a conserved, abundantly expressed protein that is partially localized
in pre-synaptic terminals in the central nervous system. The precise biological function (s) …

α-Synuclein is an abundant presynaptic brain protein, misfolding, aggregation and
fibrillation of which are implicated as critical factors in several neurodegenerative diseases …

α-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind
to lipid membranes and acquire a partial α-helical conformation. Under certain pathogenic …

The human synuclein protein family includes α-synuclein, which has been linked to both
familial and sporadic Parkinson's disease, and the highly homologous β and γ-synuclein …

Highlights•αS is a protein whose aggregation is strongly connected to Parkinson's
disease.•αS is partitioned between a disordered solution state and a helical membrane …

Under the physiological conditions in vitro, α-synuclein, a conservative presynaptic protein,
the aggregation and fibrillation of which is assumed to be involved into the pathogenesis of …

α-Synuclein (αS) is a conserved and abundant neuronal protein with unusual structural
properties. It appears to partition between folded and unstructured states as well as between …

Marta Robotta,[b] Patrick Braun,[b] Bart van Rooijen,[c] Vinod Subramaniam,*[c] Martina
Huber,*[a] and Malte Drescher*[b] α-Synuclein (αS) is a 140-residue protein abundantly …

α-Synuclein is a small cytosolic protein of presynaptic nerve terminals composed of seven
11-residue repeats and a hydrophilic tail. α-Synuclein misfolding and dysfunction may …