Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Iron is fundamental for life-essential processes. However, it can also cause oxidative
damage, which is thought to trigger numerous pathologies, including cardiovascular …

Iron accumulates in human atherosclerotic lesions but whether it is a cause or simply a
downstream consequence of the atheroma formation has been an open question for …

Iron is essential for life, while also being potentially harmful. Therefore, its level is strictly
monitored and complex pathways have evolved to keep iron safely bound to transport or …

Cells of nearly all forms of life require well-defined amounts of iron for survival, replication
and expression of differentiated processes. It has a central role in erythropoiesis but is also …

Although multiple factors are associated with cardiovascular pathology, there is now an
impressive body of evidence that free radicals and nonradical oxidants might cause a …

The catalytic role of iron in the Haber–Weiss chemistry, which results in propagation of
damaging reactive oxygen species (ROS), is well established. In this review, we attempt to …

Iron is an essential cofactor for important biological activities and biochemical reactions,
including the transport of oxygen via red blood cells and its reduction to water during …

Iron is a redox active metal involved in the oxidation-reduction reactions and regulation of
cell growth and differentiation. Iron is an integral part of many proteins and enzymes that …

Excess free iron generates oxidative stress that hallmarks diseases of aging. The
observation that patients with Alzheimer's disease or Parkinson's disease show a dramatic …