Background Although microarray technology has become the most common method for
studying global gene expression, a plethora of technical factors across the experiment …

Aims: Whole blood is likely to become the prime tissue to detect biomarkers using gene
expression analyses. In this study, we assessed whether whole-blood or globin-reduced …

Background Peripheral blood is an accessible and informative source of transcriptomal
information for many human disease and pharmacogenomic studies. While there can be …

The use of mouse blood as a model for human blood is often considered in the development
of clinically relevant, gene expression-based disease biomarkers. However, the ability to …

High-quality biomarkers for disease progression, drug efficacy and toxicity liability are
essential for improving the efficiency of drug discovery and development. The identification …

Background Transcriptome analysis is of great interest in clinical research, where significant
differences between individuals can be translated into biomarkers of disease. Although next …

The use of peripheral blood mononuclear cells (PBMC) for transcriptome analysis has
already been proven valuable for assessing disease-associated and drug-response-related …

Peripheral blood may be the most feasible tissue source in clinical assessment of
differences in gene expression between diseases and drug treatments due to accessibility …

Background Genome-wide gene expression profiling of whole blood is an attractive method
for discovery of biomarkers due to its non-invasiveness, simple clinical site processing and …

Background The molecular profile of circulating blood can reflect physiological and
pathological events occurring in other tissues and organs of the body and delivers a …