Alterations in the global methylation of DNA and in specific regulatory genes are two
epigenetic alterations found in cancer. However, the significance of epigenetic changes for …

Stems cells of the colon crypt are the origin of colon mature cells. Colorectal cancer cells are
also suggested to originate from crypt stem cells undergoing a series of epigenetic and …

The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the
disease resulted from the accumulation of mutations in oncogenes and tumor suppressor …

Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains
to be one of the most common causes of cancer-related death. CRC arises through …

Background/Aim: Cancer-associated fibroblasts (CAFs) play an important role in tumor
development and progression. The prevailing consensus favors the view that a specific …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Aberrant DNA methylation is a common epigenetic alteration involved in colorectal cancer
(CRC). In our previous study, we performed methylated DNA immunoprecipitation‐on‐chip …

Background Epigenetic alterations of specific genes have been reported to be related to
colorectal cancer (CRC) transformation and would also appear to be involved in the early …

Some colon cancer (CC) patients present synchronous cancers at diagnosis and others
develop metachronous neoplasms, but the risk factors are unclear for non-hereditary CC …

CpG island methylation in the promoter regions of tumor suppressor genes has been shown
to occur in normal colonic tissue and can distinguish between subjects with and without …