Bone morphogenic protein (BMP) signaling is essential for the coordinated assembly of the
synapse, but we know little about how BMP signaling is modulated in neurons. Our findings …

The structure and function of synapses is modulated by the interaction of presynaptic and
postsynaptic neurons via cell adhesion molecules or secreted signal molecules. Bone …

The coordinated growth and development of synapses is critical for all aspects of neural
circuit function and mutations that disrupt these processes can result in various neurological …

Activins are members of the TGF-ß superfamily of secreted growth factors that control a
diverse array of processes in vertebrates including endocrine function, cell proliferation …

At the Drosophila neuromuscular junction (NMJ), the loss of retrograde, trans-synaptic BMP
signaling causes motoneuron terminals to have fewer synaptic boutons, whereas increased …

Inhibition of postsynaptic glutamate receptors at the Drosophila NMJ initiates a
compensatory increase in presynaptic release termed synaptic homeostasis. BMP signaling …

At the Drosophila NMJ, BMP signaling is critical for synapse growth and homeostasis.
Signaling by the BMP7 homolog, Gbb, in motor neurons triggers a canonical pathway …

Drosophila Nemo is the founding member of the Nemo-like kinase (Nlk) family of
serine/threonine protein kinases that are involved in several Wnt signal transduction …

The Drosophila neuromuscular junction (NMJ) is capable of rapidly budding new
presynaptic varicosities over the course of minutes in response to elevated neuronal activity …

Publisher Summary This chapter discusses the molecular mechanisms of retrograde
signaling at the Drosophila neuromuscular junction (NMJ). Retrograde signaling regulates …