BMPs pattern the dorsal–ventral axis of vertebrate embryos. Smad1/5/8 transduces the BMP
signal, and receives phosphorylation inputs from both MAPK and GSK3. Phosphorylation of …

Signaling downstream of BMP receptors relies on activated nuclear Smad proteins. Recent
studies, one of which is published in the November 30 issue of Cell, shed light on a …

The intensity of the BMP signal is determined by cell surface receptors that phosphorylate
Smad1/5/8 at the C-terminus. In addition to this BMP-activated phosphorylation, recent …

BMP receptors determine the intensity of BMP signals via Smad1 C-terminal
phosphorylations. Here we show that a finely controlled cell biological pathway terminates …

Smad proteins convey canonical intracellular signals for activated receptors in the TGFβ
superfamily, but the activity of Smads and their impact on target genes are further regulated …

Integration of diverse signaling pathways is essential in development and homeostasis for
cells to interpret context-dependent cues. BMP and MAPK signaling converge on Smads …

Cellular responses to Bmp ligands are regulated at multiple levels, both extracellularly and
intracellularly. Therefore, the presence of these growth factors is not an accurate indicator of …

Bone morphogenetic proteins (BMPs) participate in the development of nearly all organs
and tissues. BMP signaling is mediated by specific Smad proteins, Smad1 and/or Smad5 …

Smad4 is a major tumor suppressor currently thought to function constitutively in the
transforming growth factor β (TGF-β)-signaling pathway. Here, we report that Smad4 activity …

The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window
on an entirely unique signalling pathway that functions to mediate responses to the tumour …