With contrasting observations on the effects of β-catenin on hematopoietic stem cells
(HSCs), the precise role of Wnt/β-catenin signals on HSC regulation remains unclear. Here …

Importance of the field: Microenvironment has emerged as crucial element in the regulation
of hematopoietic stem cells (HSCs) in the stem cell niche. Recent studies have …

Hematopoiesis is dependent upon the bone marrow microenvironment, which is comprised
of multiple mesenchymal cell types, including fibroblasts, endothelial cells, osteoblasts, and …

Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via
their ability to self-renew and to differentiate into all blood lineages. Although a central role …

Wingless (Wnt) is a potent morphogen demonstrated in multiple cell lineages to promote the
expansion and maintenance of stem and progenitor cell populations. Wnt effects are highly …

The bone marrow (BM) niche is a specific physiological environment for hematopoietic and
non-hematopoietic stem cells (HSCs). Several signaling pathways (including Wnt/β-catenin) …

Hematopoietic stem cells (HSCs) are a rare population of cells that are responsible for life-
long generation of blood cells of all lineages. In order to maintain their numbers, HSCs must …

The mechanisms that regulate hematopoietic stem cell (HSC) fate decisions between
proliferation and multilineage differentiation are unclear. Members of the Wnt family of …

β-catenin–mediated Wnt signaling has been suggested to be critically involved in
hematopoietic stem cell maintenance and development of T and B cells in the immune …

Gain of Wnt signaling through β-catenin has been ascribed a critical function in the
stimulation of hematopoietic stem cell self-renewal, whereas loss of β-catenin is reportedly …