The exceeding efforts in understanding the signals initiated by nutrients and hormones in
the central nervous system (CNS) to regulate glucose and energy homeostasis have largely …

Obesity and type 2 diabetes mellitus (T2DM)—disorders of energy homeostasis and glucose
homeostasis, respectively—are tightly linked and the incidences of both conditions are …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

As obesity, diabetes, and associated comorbidities are on a constant rise, large efforts have
been put into better understanding the cellular and molecular mechanisms by which …

Abstract Changes in physical activities and feeding habits have transformed the historically
rare disease of obesity into a modern metabolic pandemic. Obesity occurs when energy …

Recent evidence highlights the important role of the brain in the control of glucose
homeostasis. Hypothalamic centers sense the availability of peripheral nutrients via …

The incidences of both obesity and type 2 diabetes mellitus are rising at epidemic
proportions. Despite this, the balance between caloric intake and expenditure is …

The past decade has greatly increased our understanding and appreciation of the ability of
the central nervous system (CNS) to regulate food intake and body weight. This was …

The central nervous system (CNS) is capable of gathering information on the body's
nutritional state and it implements appropriate behavioral and metabolic responses to …

Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …