Neuroadaptations in the prefrontal cortex (PFC) are hypothesized to play an important role
in the behavioral changes associated with repeated psychostimulant exposure, but there are …

Publisher Summary This chapter discusses the central role of the basal ganglia in the
pathophysiology of stimulant addiction. It describes drug addiction as a compulsive incentive …

Neurogenesis is important for developing certain forms of memory. Recently, hippocampal
cell proliferation has been implicated in the development of drug addiction, an extreme form …

This is the final volume in a three-volume work that has addressed the scientific
methodologies relevant to clinical neurobehavioral toxicology. Volume I focused on basic …

Animal models are important in exploring the mechanisms underlying a human disease and
designing new therapies. Schizophrenia is an example of a particularly formidable …

Publisher Summary This chapter demonstrates that psychostimulants alter the expression of
perhaps hundreds of genes in the cortex and the basal ganglia. These include effector …

Numerous studies in this lab and others have reported psychostimulant-induced alterations
in both synaptic protein expression and synaptic density in striatum and prefrontal cortex …

Agmatine is an endogenous amine derived from l-arginine that potentiates morphine
analgesia and inhibits naloxone precipitated abstinent symptoms in morphine dependent …

Current research on alcohol and drug dependence gradually showed that the development
of addiction has to be understood as a complex interplay of psychological factors and …

We identify a novel transcriptional regulator of dentate granule neuron maturation, Krüppel-
like factor 9 (Klf-9). We show that Klf-9 expression is induced by neuronal activity and as …