Presenilin 1 (PS1) mutations are responsible for many early-onset familial Alzheimer's
disease (FAD) cases. While increasing evidence points to impaired synaptic plasticity as an …

Age-associated changes in the reproductive hormones—the gonadal steroid hormones and
the gonadotropins—have been identified as potential risk factors for Alzheimer's disease …

Amyloid β-peptides is the generic term for a set of hydrophobic peptides that accumulate in
Alzheimer's disease (AD)-affected brains. These amyloid-β peptide fragments are mainly …

Genetically modified mouse models have been proven to be a powerful tool in drug
discovery. The ability to genetically modify the mouse genome by removing or replacing a …

Proteolytic processing of the amyloid precursor protein (APP) generates large soluble APP
derivatives, β-amyloid (Aβ) peptides, and APP intracellular domain. Expression of the …

Pathological hallmarks of Alzheimer's disease include memory deficits, accumulation of
amyloid beta (Aβ) plaques, the appearance of neurofibrillary tangles, and dysregulation of …

Mutations in PSEN genes, which encode presenilin proteins, cause familial early‐onset
Alzheimer′ s disease (AD). Transgenic mouse models based on coexpression of familial …

AIM OF THE STUDY: Puerarin (Pur) is a primary component of the most functional extracts of
Pueraria lobata used in traditional Chinese medicine for centuries. Since it has been …

Monoclonal antibodies are highly specific for antigens of interest, and have been widely
used for many purposes. For their generation, antigen-sensitized B lymphocytes need to be …

Mutations in presenilin l gene (PS1) account for the majority of early-onset familial
Alzheimer's disease (FAD) cases. The disease is characterized by intracellular …