Continuous turnover of intracellular components by autophagy is necessary to preserve
cellular homeostasis in all tissues. Alterations in macroautophagy, the main process …

The lysosome-mediated degradation pathway known as macroautophagy is the most
versatile means through which cells can eliminate and recycle unwanted materials. Through …

Autophagy contributes to the removal of prone-to-aggregate proteins, but in several
instances these pathogenic proteins have been shown to interfere with autophagic activity …

Autophagy is an important biological process that is essential for the removal of damaged
organelles and toxic or aggregated proteins by delivering them to the lysosome for …

Autophagy is an essential cellular pathway for degrading defective organelles and
aggregated proteins. Defects in autophagy have been implicated in the neurodegenerative …

Highlights•The two major protein degradation pathways, the UPS and autophagy, are
impaired in HD.•Dysfunctional macroautophagy, including abnormal cargo recognition, is …

Macroautophagy (henceforth referred to simply as autophagy) is a bulk degradation process
involved in the clearance of long-lived proteins, protein complexes and organelles. A portion …

Autophagy is a nonspecific bulk degradation pathway for long‐lived cytoplasmic proteins,
protein complexes, or damaged organelles. This process is also a major degradation …

Efficient protein turnover is essential for the maintenance of cellular health. Here we review
how autophagy has fundamental functions in cellular homeostasis and possible uses as a …

Autophagy is an intracellular degradation process that clears long-lived proteins and
organelles from the cytoplasm. It involves the formation of double-membraned structures …