According to the prevailing “amyloid cascade hypothesis,” genetic dementias such as
Alzheimer's disease and familial Danish dementia (FDD) are caused by amyloid deposits …

Familial dementias, which include Alzheimer disease (AD), familial British dementia (FBD),
and familial Danish dementia (FDD), are caused by dominantly inherited autosomal …

Familial British dementia (FBD) and familial Danish dementia (FDD) are two autosomal
dominant neurodegenerative diseases caused by mutations in the BRI 2 gene. FBD and …

An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia
(FDD). Analysis of FDDKI mice, a mouse model of FDD genetically congruous to the human …

Familial British Dementia (FBD) is caused by an autosomal dominant mutation in the
BRI2/ITM2B gene. FBDKI mice are a model of FBD that is genetically congruous to the …

Familial Danish dementia (FDD) is an autosomal dominant neurodegenerative disease
caused by a 10-nucleotide duplication-insertion in the BRI2 gene. FDD is clinically …

An autosomal dominant mutation in the BRI2/ITM2B gene causes Familial Danish Dementia
(FDD). We have generated a mouse model of FDD, called FDD KI, genetically congruous to …

The chromosome 13 linked amyloidopathies familial British dementia (FBd) and familial
Danish dementia (Fdd) are caused by mutations in the c‐terminus of the BRI2 gene. In both …

Familial Danish dementia (FDD) is an autosomal dominant neurodegenerative disease
clinically characterized by the presence of cataracts, hearing impairment, cerebellar ataxia …

BRI2 protein binds amyloid precursor protein to halt amyloid-β production and inhibits
amyloid-β aggregation via its BRICHOS-domain suggesting a link between BRI2 and …