Mechanisms underlying the immunomodulatory effects of n-3 PUFA

P Yaqoob - Proceedings of the Nutrition Society, 2010 - cambridge.org
The enrichment of immune cell membranes with n-3 PUFA is associated with modulation of
immune function. The degree of incorporation of n-3 PUFA (and therefore the impact of …

Effects of dietary n− 3 polyunsaturated fatty acids on T-cell membrane composition and function

KC Switzer, DN McMurray, RS Chapkin - Lipids, 2004 - Springer
Dietary n− 3 PUFA have been shown to attenuate T-cell-mediated inflammation, in part, by
suppressing T-cell activation and proliferation. n− 3 PUFA have also been shown to promote …

Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA

YY Fan, NR Fuentes, TY Hou, R Barhoumi… - British journal of …, 2018 - cambridge.org
Cell membrane fatty acids influence fundamental properties of the plasma membrane,
including membrane fluidity, protein functionality, and lipid raft signalling. Evidence suggests …

n− 3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization

DN McMurray, DL Bonilla, RS Chapkin - Chemistry and physics of lipids, 2011 - Elsevier
It is now well established that dietary lipids are incorporated into macrophage and T-cell
membrane microdomains, altering their structure and function. Within cell membranes, there …

Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease

JWC Sijben, PC Calder - Proceedings of the Nutrition Society, 2007 - cambridge.org
The balance of intake of n-6 and n-3 PUFA, and consequently their relative incorporation
into immune cells, is important in determining the development and severity of immune and …

[HTML][HTML] Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation

SR Shaikh, M Edidin - The American journal of clinical nutrition, 2006 - Elsevier
Dietary supplementation with polyunsaturated fatty acids (PUFAs), especially those of the n−
3 class, has immunosuppressive effects on both innate and adaptive immunity through …

[HTML][HTML] Narrative Review of n-3 Polyunsaturated Fatty Acid Supplementation upon Immune Functions, Resolution Molecules and Lipid Peroxidation

GP Zaloga - Nutrients, 2021 - mdpi.com
Fish oil supplementation is commonplace in human nutrition and is being used in both
enteral and parenteral formulations during the treatment of patients with a large variety of …

Omega-3 fatty acids, lipid rafts, and T cell signaling

TY Hou, DN McMurray, RS Chapkin - European journal of pharmacology, 2016 - Elsevier
Abstract n-3 polyunsaturated fatty acids (PUFA) have been shown in many clinical studies to
attenuate inflammatory responses. Although inflammatory responses are orchestrated by a …

[HTML][HTML] Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules

SR Shaikh, M Edidin - Journal of lipid research, 2007 - ASBMB
Dietary supplementation with polyunsaturated fatty acids (PUFAs) has immunosuppressive
effects; however, the molecular targets of PUFAs and their mode of action remain unclear …

Chemotherapeutic properties of n-3 polyunsaturated fatty acids-Old concepts and new insights

W Kim, DN McMurray… - Immunology, Endocrine & …, 2009 - ingentaconnect.com
Over the past several decades, data from both experimental animal studies and human
clinical trials have shown that dietary n-3 polyunsaturated fatty acids (PUFA) exhibit anti …