Gene-specific RNA polymerase II phosphorylation and the CTD code
Phosphorylation of the RNA polymerase (Pol) II C-terminal domain (CTD) repeats (1-
YSPTSPS-7) is coupled to transcription and may act as a'code'that controls mRNA synthesis …
YSPTSPS-7) is coupled to transcription and may act as a'code'that controls mRNA synthesis …
[HTML][HTML] Heptad-specific phosphorylation of RNA polymerase II CTD
The carboxy-terminal domain (CTD) of RNA polymerase II (Pol II) consists of heptad repeats
with the consensus motif Y 1-S 2-P 3-T 4-S 5-P 6-S 7. Dynamic phosphorylation of the CTD …
with the consensus motif Y 1-S 2-P 3-T 4-S 5-P 6-S 7. Dynamic phosphorylation of the CTD …
[HTML][HTML] Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
The carboxy-terminal domain (CTD) of the RNA polymerase II (Pol II) large subunit cycles
through phosphorylation states that correlate with progression through the transcription …
through phosphorylation states that correlate with progression through the transcription …
[HTML][HTML] A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes
Transcription by RNA polymerase II (RNAPII) is coupled to mRNA processing and chromatin
modifications via the C-terminal domain (CTD) of its largest subunit, consisting of multiple …
modifications via the C-terminal domain (CTD) of its largest subunit, consisting of multiple …
Uniform transitions of the general RNA polymerase II transcription complex
A Mayer, M Lidschreiber, M Siebert, K Leike… - Nature structural & …, 2010 - nature.com
We present genome-wide occupancy profiles for RNA polymerase (Pol) II, its
phosphorylated forms and transcription factors in proliferating yeast. Pol II exchanges …
phosphorylated forms and transcription factors in proliferating yeast. Pol II exchanges …
The pol II CTD: new twists in the tail
J Zaborowska, S Egloff, S Murphy - Nature structural & molecular …, 2016 - nature.com
The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises
conserved heptad repeats, and post-translational modification of the CTD regulates …
conserved heptad repeats, and post-translational modification of the CTD regulates …
[HTML][HTML] Comprehensive RNA polymerase II interactomes reveal distinct and varied roles for each phospho-CTD residue
Transcription controls splicing and other gene regulatory processes, yet mechanisms remain
obscure due to our fragmented knowledge of the molecular connections between the …
obscure due to our fragmented knowledge of the molecular connections between the …
[HTML][HTML] C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats
JC Jones, HP Phatnani, TA Haystead… - Journal of Biological …, 2004 - ASBMB
The C-terminal repeat domain (CTD) of the largest subunit of RNA polymerase II is
composed of tandem heptad repeats with consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5 …
composed of tandem heptad repeats with consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5 …
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II
A Mayer, M Heidemann, M Lidschreiber, A Schreieck… - Science, 2012 - science.org
In different phases of the transcription cycle, RNA polymerase (Pol) II recruits various factors
via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the …
via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the …
Updating the RNA polymerase CTD code: adding gene-specific layers
S Egloff, M Dienstbier, S Murphy - Trends in Genetics, 2012 - cell.com
The carboxyl-terminal domain (CTD) of RNA polymerase (pol) II comprises multiple tandem
repeats with the consensus sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 that can be …
repeats with the consensus sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 that can be …