Wnt signaling has been implicated in certain inflammatory diseases. However, the biological
role in the inflammatory regulation remains to be characterized. We investigated the …

Objective The objective of this article is to review the current literature on Wnt5a and its
signaling mechanism, along with its role in atherosclerosis. In addition, the significance of …

Wnt proteins are members of the highly conserved wingless family of proteins responsible
for cell differentiation and development and for neoplastic and degenerative processes …

The Wnt-signaling pathway plays a critical role in directing cell fate during embryogenesis.
Several lines of evidence also suggest a role in inflammatory processes. Here, we analyzed …

Cell to cell interaction is one of the key processes effecting angiogenesis and endothelial
cell function. Wnt signalling is mediated through cell–cell interaction and is involved in many …

Wnts are lipid-modified secreted glycoproteins that regulate diverse biological processes.
We report that Wnt5a, which functions in noncanonical Wnt signaling, has activity on …

Wnts are secreted signaling proteins able to control diverse biological processes such as
cell differentiation and proliferation. Many Wnts act through a canonical, β-catenin signaling …

Atherosclerosis is an inflammatory disease involving the accumulation of macrophages in
the intima. Wnt5a is a noncanonical member of the Wnt family of secreted glycoproteins …

The Wnt pathway plays a critical role in the development of multicellular organisms. 1, 2 It
shows evolutionary conservation across a wide range of species, ranging from the …

Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (β-catenin-
independent pathways). Human neutrophils expressed several Wnt5a receptors, such as …