[HTML][HTML] BRCA1 protein and nucleolin colocalize in breast carcinoma tissue and cancer cell lines

N Tulchin, M Chambon, G Juan, S Dikman… - The American journal of …, 2010 - Elsevier
The breast and ovarian cancer susceptibility gene BRCA1 encodes a tumor suppressor.
BRCA1 protein, which is involved in DNA damage response, has been thought to be found …

Localization of BRCA1 gene expression in adult cynomolgus monkey tissues

F Durocher, J Simard, J Ouellette… - … of Histochemistry & …, 1997 - journals.sagepub.com
The breast and ovarian cancer susceptibility gene BRCA1 encodes a phosphoprotein of
1863 amino acids containing a highly conserved N-terminal RING finger domain and a C …

Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations

N Tulchin, L Ornstein, S Dikman, J Strauchen… - Cancer Cell …, 2013 - Springer
Background The breast and ovarian cancer susceptibility gene (BRCA1) encodes a tumor
suppressor. The BRCA1 protein is found primarily in cell nuclei and plays an important role …

BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F …

H Wang, N Shao, QM Ding, J Cui, ESP Reddy, VN Rao - Oncogene, 1997 - nature.com
BRCA1, a familial breast and ovarian cancer susceptibility gene encodes nuclear
phosphoproteins that function as tumor suppressors in human breast cancer cells …

Increased Level of Exon 12 Alternatively Spliced BRCA2 Transcripts in Tumor Breast Tissue Compared with Normal Tissue

I Bieche, R Lidereau - Cancer research, 1999 - AACR
The breast cancer susceptibility gene BRCA2 is expressed in a wide range of tissues as an
11-kb mRNA transcript encoding a 3418-amino acid protein, which is involved in the …

Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters

Lee, Jin, Chang, Lin - Histopathology, 1999 - Wiley Online Library
Aim BRCA1, a nuclear phosphoprotein, normally functions as a negative regulator of the cell
cycle and may be an active inhibitor of neoplastic progression. Mutation of the BRCA1 gene …

Induction of apoptosis by the tumor suppressor protein BRCA1.

N Shao, YL Chai, E Shyam, P Reddy, VN Rao - Oncogene, 1996 - europepmc.org
The breast and ovarian cancer susceptibility gene BRCA1, is a nuclear phosphoprotein
which functions as a tumor suppressor. To investigate the role of BRCA1 in apoptosis, we …

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

CA Wilson, MN Payton, GS Elliott, FW Buaas… - Oncogene, 1997 - nature.com
The mechanism of BRCA1 tumor suppression in human breast and ovarian cells is the focus
of intense investigation. In this report, full length BRCA1 (230 kDa) introduced into cells with …

Expression of BRCA1 protein in breast cancer and its prognostic significance

EA Rakha, SE El-Sheikh, MA Kandil, ME El-Sayed… - Human pathology, 2008 - Elsevier
BRCA1 is a tumor suppressor gene which, when mutated, is associated with the
development of hereditary breast cancers. In sporadic tumors, although inherent gene …

BRCA1: exploring the links to transcription

ANA Monteiro - Trends in biochemical sciences, 2000 - cell.com
Progress on determining the function of the breast and ovarian cancer susceptibility gene
BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and …