Allergic diseases such as asthma result from inappropriate immunologic responses to
common environmental allergens in genetically susceptible individuals. Following allergen …

Growing evidence suggests that anaphylatoxins, C3a and C5a, play important roles in
innate immunity and may also participate in the pathogenesis of asthma. Previous studies …

The complement system forms the central core of innate immunity but also mediates a
variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of …

Complement component 5 (C5) has been described as either promoting or protecting
against airway hyperresponsiveness (AHR) in experimental allergic asthma, suggesting …

The complement system has long been recognized for its role as a lytic effector system that
protects against microbial pathogens, as well as for its role in mediating acute and chronic …

Despite extensive inquiry, the mechanisms underlying the pathophysiology of allergic
diseases remain unknown. Recently, there has been a resurgence of interest in the role of …

Background Mast cells (MC) are key effector cells of allergic diseases and resistance to
helminthic parasites and induce or amplify diverse innate and adaptive immune responses …

BACKGROUND: Mast cells express receptors for complement anaphylatoxins C3a and C5a
(ie, C3a receptor [C3aR] and C5a receptor [C5aR]), and C3a and C5a are generated during …

Asthma is a chronic inflammatory disease of the lung resulting in airway obstruction. The
airway inflammation of asthma is strongly linked to Th2 lymphocytes and their cytokines …

Airway hyperresponsiveness and airway inflammation are hallmarks of allergic asthma, the
etiology of which is crucially linked to the presence of Th2 cytokines. A role for the …