Mutual pharmacokinetic interactions between bosentan and lopinavir/ritonavir in healthy participants

J Dingemanse, PLM van Giersbergen… - Antiviral …, 2010 - journals.sagepub.com
Background We aimed to investigate the extent of pharmacokinetic drug interactions
between bosentan and a fixed combination of lopinavir/ritonavir. Methods This was a three …

Pharmacokinetic interactions between the hepatitis C virus protease inhibitor boceprevir and ritonavir-boosted HIV-1 protease inhibitors atazanavir, darunavir, and …

EGJ Hulskotte, HP Feng, F Xuan… - Clinical infectious …, 2013 - academic.oup.com
Background. Boceprevir represents a new treatment option for hepatitis C (HCV)–infected
patients, including those with HCV/human immunodeficiency virus coinfection; however …

Evaluation of the pharmacokinetic drug-drug interaction between the antiretroviral agents fostemsavir and maraviroc: a single-sequence crossover study in healthy …

MB Wire, M Magee, P Ackerman… - HIV Research & …, 2022 - Taylor & Francis
Background Fostemsavir is an oral prodrug of temsavir, a first‐in‐class attachment inhibitor
that binds HIV‐1 gp120, preventing initial HIV attachment and entry into host immune cells …

An open-label crossover study to evaluate potential pharmacokinetic interactions between oral oseltamivir and intravenous zanamivir in healthy Thai adults

S Pukrittayakamee, P Jittamala… - Antimicrobial agents …, 2011 - Am Soc Microbiol
There is no parenteral formulation of the neuraminidase inhibitor oseltamivir, the most
widely used anti-influenza virus drug. Oseltamivir resistance is an increasing problem …

Lopinavir/Ritonavir Pharmacokinetic Profile: Impact of Sex and Other Covariates Following a Change From Twice‐Daily to Once‐Daily Therapy

I Ofotokun, SK Chuck, JN Binongo… - The Journal of …, 2007 - Wiley Online Library
The aim of this study was to determine the impact of sex on the pharmacokinetics of
lopinavir/ritonavir. Interaction between lopinavir/ritonavir and tenofovir was also evaluated …

Pharmacokinetic interaction between boceprevir and etravirine in HIV/HCV seronegative volunteers

KP Hammond, P Wolfe, JR Burton Jr… - JAIDS Journal of …, 2013 - journals.lww.com
Objective: The primary aim of this study was to determine the bioequivalence of boceprevir,
an HCV protease inhibitor and etravirine, an HIV non–nucleoside reverse transcriptase …

Assessment of pharmacokinetic interaction between letermovir and fluconazole in healthy participants

A Adedoyin, C Fancourt, K Menzel… - Clinical …, 2021 - Wiley Online Library
Letermovir is a prophylactic agent for cytomegalovirus infection and disease in adult
cytomegalovirus‐seropositive recipients of allogeneic hematopoietic stem cell transplant. As …

Effect of renal and hepatic impairment on the pharmacokinetics of temsavir, the active moiety of fostemsavir

M Magee, J Slater, F Mannino… - The Journal of …, 2021 - Wiley Online Library
The oral prodrug fostemsavir (GSK3684394, formerly BMS‐663068) is an antiretroviral
treatment for HIV‐1. Fostemsavir is metabolized to its active moiety, temsavir, a first‐in‐class …

Population pharmacokinetics of oseltamivir and oseltamivir carboxylate in obese and non‐obese volunteers

K Chairat, P Jittamala, W Hanpithakpong… - British Journal of …, 2016 - Wiley Online Library
Aims The aims of the present study were to compare the pharmacokinetics of oseltamivir
and its active antiviral metabolite oseltamivir carboxylate in obese and non‐obese …

[HTML][HTML] Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the monitoring of temsavir plasma concentrations in …

P Thoueille, U Seybold, LA Decosterd… - … of Chromatography B, 2023 - Elsevier
A majority of people living with HIV (PLWH) now have access to HIV treatment with high
antiviral potency and favorable tolerability profile. However, in some treatment experienced …