Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide
potential routes towards generation of patient specific embryonic stem (ES) cells. These …

Methodologies to reprogram somatic cells into patient-specific pluripotent cells, which could
potentially be used in personalized drug discovery and cell replacement therapies, are …

Embryonic Stem Cells (ES cells) exhibit vast potential that is just beginning to be realized
with regard to both clinical therapies, and use in the laboratory as a model system for the …

Oct4 is one of the most important transcription factors required to maintain an
undifferentiated state (self-renewal) and pluripotency of human and mouse embryonic stem …

The transcription factor Oct4 plays a central role in controlling the undifferentiated state of
embryonic and induced pluripotent stem cells. Two complementary papers in this issue of …

Pluripotency, a characteristic of cells in the inner cell mass of the mammalian
preimplantation blastocyst as well as of embryonic stem cells, is defined as the ability of a …

Pluripotent embryonic stem cells (ESCs) maintain self-renewal while ensuring a rapid
response to differentiation cues. The identification of genes maintaining ESC identity is …

Our knowledge of the molecular mechanisms underlying human embryonic stem cell
(hESC) self-renewal and differentiation is incomplete. The level of octamer-binding …

Mammalian cell totipotency is a subject that has fascinated scientists for generations. A long
lasting question whether some of the somatic cells retains totipotency was answered by the …

The transcription factor Oct4 is well defined as a key regulator of embryonic stem (ES) cell
pluripotency. In recent years, the role of Oct4 has purportedly extended to the self renewal …