The trifluoromethyl group can dramatically influence the properties of organic molecules,
thereby increasing their applicability as pharmaceuticals, agrochemicals, or building blocks …

Difluoromethylated aromatic compounds are of increasing importance in pharmaceuticals,
agrochemicals and materials. Chlorodifluoromethane (ClCF2H), an inexpensive, abundant …

A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and
iodides under mild conditions is described. A wide range of heteroaryl halides such as …

Difluoromethylated arenes are one of the privileged structural motifs that are important for
fine tuning the biological properties of drug molecules. No general catalytic method exists for …

The incorporation of fluorine-containing moieties into organic compounds is of great
importance in pharmaceutical, agricultural, and materials science. Transition-metal …

Owing to the excellent performance of fluorinated compounds in the areas of
pharmaceuticals, agrochemicals, and materials chemistry, organic chemists have made …

Recent advances in catalysis have made the incorporation of fluorine into complex organic
molecules easier than ever before, but selective, general and practical fluorination reactions …

Relatively low reactivity hinders using chlorodifluoromethane (ClCF2H) for general
difluoromethylation with organic molecules, despite its availability as an inexpensive …

The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C–H bond directed by
an acetamino group is reported. This method provides an efficient and green approach to …

Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the
importance of the difluoromethyl group in medical, agro‐, and materials chemistry. A …