The calcium ion (Ca2+) plays fundamental roles in orchestrating dynamic changes in the
function and structure of nerve cell circuits in the brain. The endoplasmic reticulum (ER), an …

Sustained imbalance in intracellular calcium (Ca2+) entry and clearance alters cellular
integrity, ultimately leading to cellular homeostasis disequilibrium and cell death …

Ca2+ ions subserve complex signaling roles in neurons, regulating functions ranging from
gene transcription to modulation of membrane excitability. Ca2+ ions enter the cytosol from …

Alzheimer disease (AD) is a major threat of twenty-first century that is responsible for the
majority of dementia in the elderly. Development of effective AD-preventing therapies are the …

Emerging evidence indicates that Ca2+ is a vital factor in modulating the pathogenesis of
Alzheimer's disease (AD). In healthy neurons, Ca2+ concentration is balanced to maintain a …

Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from
the degeneration of synapses and death of neurons in the limbic system and associated …

Alzheimer's disease (AD) is a devastating neurodegenerative condition with no known cure.
While current therapies target late-stage amyloid formation and cholinergic tone, to date …

Perturbed neuronal Ca 2+ homeostasis is implicated in age-related cognitive impairment
and Alzheimer's disease (AD). With advancing age, neurons encounter increased oxidative …

In this mini-review/opinion article we describe evidence that multiple cellular and molecular
alterations in Alzheimer's disease (AD) pathogenesis involve perturbed cellular calcium …

Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+
dyshomeostasis can lead to widespread impairment of cellular and synaptic signaling …