Omega-3 and Omega-6 fatty acids kill thymocytes and increase membrane fluidity

A Prasad, M Åhs, A Goncharov… - The Open Cell …, 2010 - benthamopen.com
Background: Omega-3 but not omega-6 fatty acids are thought to promote cardiovascular
health by increasing membrane fluidity. Methods: The actions of acute application of omega …

Role of calcium and ROS in cell death induced by polyunsaturated fatty acids in murine thymocytes

A Prasad, MS Bloom… - Journal of cellular …, 2010 - Wiley Online Library
We investigated the mechanisms whereby omega‐3 and‐6 polyunsaturated fatty acids
(PUFAs) cause cell death of mouse thymocytes using flow cytometry, focusing on the …

Effects of cholesterol and docosahexaenoic acid on cell viability and (Ca2+)i levels in acutely isolated mouse thymocytes

S Sandal, J Tuneva, B Yilmaz… - Cell Biochemistry and …, 2009 - Wiley Online Library
We investigated the effects of lipids on thymocyte function. The effects of application of
cholesterol or docosahexaenoic acid (DHA), a C22, omega‐3 (n‐3) polyunsaturated fatty …

Mechanisms of cell death of thymocytes induced by polyunsaturated, monounsaturated and trans‐fatty acids

M Åhs, A Prasad, Z Aminov… - Journal of cellular …, 2011 - Wiley Online Library
Polyunsaturated fatty acids (PUFAs) are rapidly cytotoxic to isolated murine thymocytes, and
the degree of cell death has been correlated with changes in membrane fluidity, elevation of …

Effect of omega‐3 fatty acid supplementation on indicators of membrane fluidity

A Carughi, LT Huynh, D Perelman - The FASEB Journal, 2010 - Wiley Online Library
Membrane fluidity is a central aspect of cell physiology that can be modulated by fatty acid
(FA) intake. Increasing dietary omega‐3 fatty acids (n‐3 FA) increases n‐3 FA in membrane …

Phospholipase D as a potential target for the antiproliferative effects of polyunsaturated fatty acids in rat thymocytes

A Benzaria, N Meskini, M Dubois, G Némoz… - The Journal of …, 2007 - Elsevier
The effects of various saturated and unsaturated fatty acids (FAs) on the proliferative
response and phospholipase D (PLD) activity of rat thymocytes were investigated. When …

Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells

M Hashimoto, MS Hossain, H Yamasaki, K Yazawa… - Lipids, 1999 - Wiley Online Library
We investigated the relative effects of n− 3 eicosapentaenoic acid (EPA, 20∶ 5n− 3) and
docosahexaenoic acid (DHA, 22∶ 6n− 3) on the plasma membrane fluidity of endothelial …

Differential effects of eicosapentaenoic acid and docosahexaenoic acid on human skin fibroblasts

ER Brown, PV Subbaiah - Lipids, 1994 - Wiley Online Library
To better understand the mode of action of ω3 fatty acids in cell membranes, human foreskin
fibroblasts were grown in serum‐free medium supplemented with 50 μM oleic acid linoleic …

Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in Th1-polarized murine CD4+ T-cells

KC Switzer, YY Fan, N Wang, DN McMurray… - Journal of lipid …, 2004 - ASBMB
Dietary n-3 PUFAs have been shown to attenuate T-cell-mediated inflammation. To
investigate whether dietary n-3 PUFAs promote activation-induced cell death (AICD) in …

Antiinflammatory effects of ω-3 fatty acids vary at different stages of inflammation

B Nohé, T Johannes… - American Journal of …, 2003 - journals.physiology.org
J Physiol Heart Circ Physiol 283: H811–818, 2003; 10.1152/ajpheart. 00235.2002.—
Monocyte-endothelium interaction is a fundamental process in many acute and chronic …