Invariant natural killer T cell-based therapy of autoimmune diseases

CL Gabriel, L Wu, VV Parekh… - Current Immunology …, 2010 - ingentaconnect.com
Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes that share
characteristics with both innate and adaptive immune cells. The iNKT cell receptor …

Invariant natural killer T cells: innate‐like T cells with potent immunomodulatory activities

L Wu, CL Gabriel, VV Parekh, L Van Kaer - Tissue antigens, 2009 - Wiley Online Library
Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that react with glycolipid
antigens presented by the major histocompatibility complex class I‐related glycoprotein …

The role of invariant natural killer T Cells in autoimmune diseases

G Wingender, M Kronenberg - The Autoimmune Diseases, 2020 - Elsevier
Invariant natural killer T (i NKT) cells are a unique subset of T lymphocytes characterized by
the expression of an invariant T-cell antigen receptor rearrangement, and the recognition of …

Invariant natural killer T cells: bridging innate and adaptive immunity

L Van Kaer, VV Parekh, L Wu - Cell and tissue research, 2011 - Springer
Cells of the innate immune system interact with pathogens via conserved pattern-recognition
receptors, whereas cells of the adaptive immune system recognize pathogens through …

[HTML][HTML] A Humanized Monoclonal Antibody Specific for Invariant Natural Killer T (iNKT) Cells for In Vivo Depletion

F Scheuplein, A Thariath, S Macdonald, A Truneh… - PLoS …, 2013 - journals.plos.org
Invariant Natural Killer T (iNKT) cells are a subset of T cells recognizing glycolipid antigens
presented by CD1d. Human iNKT cells express a conserved T cell receptor (TCR)-α chain …

Challenges of iNKT cell-based antitumor immunotherapies

H Zhang, L Bai - Cellular & molecular immunology, 2021 - nature.com
Invariant natural killer T (iNKT) cells are good candidates for antitumor immunotherapies
due to their functional advantages and low toxicity. Their promising utility has been exhibited …

[HTML][HTML] Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo

F Scheuplein, DJ Lamont, ME Poynter, JE Boyson… - PLoS …, 2015 - journals.plos.org
Invariant Natural Killer T (iNKT) cells are a T cell subset expressing an invariant T Cell
Receptor (TCR) that recognizes glycolipid antigens rather than peptides. The cells have …

Invariant natural killer T cells as sensors and managers of inflammation

L Van Kaer, VV Parekh, L Wu - Trends in immunology, 2013 - cell.com
Invariant natural killer T (iNKT) cells are a subset of innate-like lymphocytes that recognize
glycolipid antigens bound by the major histocompatibility complex (MHC)-class-I-related …

The interaction between iNKT cells and B cells

T Zhu, R Wang, H Miller, LS Westerberg… - Journal of Leukocyte …, 2022 - academic.oup.com
Invariant natural killer T cells (iNKTs) bridge the innate immunity with the adaptive immunity
and their interaction with B cells has been extensively studied. Here, we give a complete …

Role of invariant natural killer T cells in immune regulation and as potential therapeutic targets in autoimmune disease

L Van Kaer - Expert Review of Clinical Immunology, 2006 - Taylor & Francis
Autoimmune diseases are caused by pathogenic antibody and/or T-cell responses that are
left unchecked by regulatory immune mechanisms. Recent studies in immunology have …