Nrf2 transcription factor plays a crucial role in protection of cells against oxidative stress.
Under normal conditions Nrf2 is sequestered in cytoplasm by a cytoskeletal protein, Keapl …

Due to that at present, the majority of diseases are associated with alterations in oxidative
stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; …

The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/NRF2) is a master
transcription factor that regulates oxidative stress-related genes containing the antioxidant …

NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates,
suggesting an intimate connection between injured brain and loss of proteostasis …

Clinical and preclinical research indicates that neurodegenerative diseases are
characterized by excess levels of oxidative stress (OS) biomarkers and by lower levels of …

Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Living organisms come under attack from multiple environmental factors, which can lead to
the production of reactive oxygen species (ROS) and electrophiles. This results in oxidative …

A wide range of experimental and observational studies have established the irrefutable role
of oxidative stress in the pathogenesis of a plethora of diseases either directly or indirectly …

The transcription factor Nrf2 has emerged as a master regulator of the endogenous
antioxidant response, which is critical in defending cells against environmental insults and in …