Genomics of pulmonary arterial hypertension: implications for therapy

MW Geraci, TM Bull, RM Tuder - Heart failure clinics, 2010 - heartfailure.theclinics.com
The first descriptions of pulmonary arterial hypertension (PAH) have fascinated clinicians
and scientists since these brief initial descriptions. Despite significant advances in the …

[HTML][HTML] The role of genomics and genetics in pulmonary arterial hypertension

EM Swietlik, S Gräf, NW Morrell - Global Cardiology Science & …, 2020 - ncbi.nlm.nih.gov
Although pulmonary hypertension (PH) had been recognised for centuries, it was not until
the invention of cardiac catheterisation in the 1950s that enabled an accurate clinical …

Genetics and genomics of pulmonary arterial hypertension

NW Morrell, MA Aldred, WK Chung… - European …, 2019 - Eur Respiratory Soc
Since 2000 there have been major advances in our understanding of the genetic and
genomics of pulmonary arterial hypertension (PAH), although there remains much to …

Genetics and genomics of pulmonary arterial hypertension

F Soubrier, WK Chung, R Machado, E Grünig… - Journal of the American …, 2013 - jacc.org
Major discoveries have been obtained within the last decade in the field of hereditary
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of …

[HTML][HTML] Translational Advances in the Field of Pulmonary Hypertension Molecular Medicine of Pulmonary Arterial Hypertension. From Population Genetics to …

ED Austin, J West, JE Loyd… - American Journal of …, 2017 - atsjournals.org
An improved understanding of the molecular causes and modifiers of pulmonary arterial
hypertension (PAH) has emerged during the last several decades. However, the survival of …

Molecular medicine of pulmonary arterial hypertension: from population genetics to precision medicine and gene editing

ED Austin, J West, JE Loyd… - American journal of …, 2017 - search.proquest.com
An improved understanding of the molecular causes and modifiers of pulmonary arterial
hypertension (PAH) has emerged during the last several decades. However, the survival of …

Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives

P Chelladurai, W Seeger… - European Respiratory …, 2016 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a severe and progressive disease, characterised
by high pulmonary artery pressure that usually culminates in right heart failure. Recent …

[HTML][HTML] Mechanisms of disease: pulmonary arterial hypertension

RT Schermuly, HA Ghofrani, MR Wilkins… - Nature Reviews …, 2011 - nature.com
Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

The genetics of pulmonary arterial hypertension

ED Austin, JE Loyd - Circulation research, 2014 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease for which there is
an ever-expanding body of genetic and related pathophysiological information on disease …

Molecular genetic framework underlying pulmonary arterial hypertension

L Southgate, RD Machado, S Gräf… - Nature Reviews …, 2020 - nature.com
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder typified by occlusion
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …