Introduction• Dysregulation of Ca2+ homeostasis in AD‐Aβ accumulation causes Ca2+
dyshomeostasis‐Ca2+ dyshomeostasis increases Aβ production• Presenilins and Ca2+ …

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is
at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

Emerging evidence indicates that Ca2+ is a vital factor in modulating the pathogenesis of
Alzheimer's disease (AD). In healthy neurons, Ca2+ concentration is balanced to maintain a …

Dysregulation of intracellular Ca 2+ homeostasis has been proposed as a common proximal
cause of neural dysfunction during aging and Alzheimer's disease (AD). In this context …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Alzheimer's disease (AD) is a neurodegenerative pathology representing a socioeconomic
challenge, however, the complex mechanism behind the disease is not yet fully understood …

Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder
with no known cure or clear understanding of the mechanisms involved in the disease …

Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from
the degeneration of synapses and death of neurons in the limbic system and associated …

Calcium is involved in many facets of neuronal physiology, including activity, growth and
differentiation, synaptic plasticity, and learning and memory, as well as pathophysiology …