Rethinking schizophrenia
TR Insel - Nature, 2010 - nature.com
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …
disabling mental disorder that affects about one per cent of the world's population. After a …
Puzzling over schizophrenia: schizophrenia as a pathway disease
PF Sullivan - Nature medicine, 2012 - nature.com
Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems
associated with cognitive impairment and finding the root of the disease remain priorities for …
associated with cognitive impairment and finding the root of the disease remain priorities for …
Genesis of a complex disease
J Flint, M Munafo - Nature, 2014 - nature.com
Genesis of a complex disease | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …
You are using a browser version with limited support for CSS. To obtain the best experience …
De novo mutations in schizophrenia implicate synaptic networks
Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
[引用][C] Splitting schizophrenia
ES Lander - Nature, 1988 - nature.com
Splitting schizophrenia Page 1 © 1988 Nature Publishing Group _N_A_T_ll_R_E_V_(_)l_ ..
_.1_.IC_, _111_N_(_JV_E_.M_B_E_"R_llJ_H_K _ _ _ _ _ _ NEWS AND VIEWS------------------I_OS …
_.1_.IC_, _111_N_(_JV_E_.M_B_E_"R_llJ_H_K _ _ _ _ _ _ NEWS AND VIEWS------------------I_OS …
Advances in schizophrenia
GK Thaker, WT Carpenter - Nature medicine, 2001 - nature.com
Recent studies into the etiology of schizophrenia have yielded both promising leads and
disappointing dead ends, indicating the multifactored and complex nature of the disorder …
disappointing dead ends, indicating the multifactored and complex nature of the disorder …
Schizophrenia.
MJ Owen, A Sawa, PB Mortensen - Lancet (London, England), 2016 - europepmc.org
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome whose
origins appear to lie in genetic and/or environmental disruption of brain development …
origins appear to lie in genetic and/or environmental disruption of brain development …
What are the right targets for psychopharmacology?
SE Hyman, WS Fenton - Science, 2003 - science.org
We would argue that clinical neuroscience has already provided the tools to test hypotheses
in treatment research that are at least partly independent of current classifications …
in treatment research that are at least partly independent of current classifications …
Pathophysiologically based treatment interventions in schizophrenia
DA Lewis, G Gonzalez-Burgos - Nature medicine, 2006 - nature.com
Identifying the molecular alterations that underlie the pathophysiology of critical clinical
features of schizophrenia is an essential step in the rational development of new therapeutic …
features of schizophrenia is an essential step in the rational development of new therapeutic …
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Indonesia Schizophrenia Consortium… - Nature, 2022 - research.vu.nl
Schizophrenia has a heritability of 60-80% 1, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …