Signals generated by the dynamic mechanical strain critically regulate endothelial cell
proliferation and angiogenesis; however, the molecular basis remains unclear. We …

Background Angiogenesis, or the growth of new vasculature from existing blood vessels, is
widely considered a primary hallmark of cancer progression. When a tumor is small …

Introduction The goal of this study was to investigate how concurrent shear stress and
tensile strain affect endothelial cell biomechanical responses. Methods Human coronary …

VEGF and MMP protein production are both required for exercise‐induced capillary growth
in skeletal muscle. The underlying process by which muscle activity initiates an angiogenic …

The vascular wall is an integrated functional component of the circulatory system that is
continually remodelling or is developing atherosclerosis in response to hemodynamic or …

Mechanical forces are potent modulators of the growth and hypertrophy of vascular cells. We
examined the molecular mechanisms through which mechanical force and hypertension …

Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis
and mediate several pathological and physiological processes. Mechanical stresses …

The vascular endothelium is constantly exposed to mechanical forces, including fluid shear
stress exerted by the flowing blood. Endothelial cells can sense different flow patterns and …

Tissue homeostasis is not only controlled by biochemical signals but also through
mechanical forces that act on cells. Yet, while it has long been known that biochemical …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …