This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

Ischemic stroke triggers a complex and highly interconnected cascade of cellular and
molecular events. Early events induced following ischemic injury, including excitotoxicity …

Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …

Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available …

Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …

Ischemic stroke is the second most common cause of death worldwide and a major cause of
disability. Intravenous thrombolysis with rt-PA remains the only available acute therapy in …

Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

Ischemic stroke remains a leading cause of morbidity and death for which few therapeutic
options are available. The development of neuroprotective agents, a once promising field of …

The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …