Abstract Mutations in presenilin-1 (PS1) and presenilin-2 (PS2) cause familial Alzheimer's
disease (FAD). Presenilins influence multiple molecular pathways and are best known for …

Presenilin-1 (PS1) mutations account for the greatest portion of early onset familial
Alzheimer's disease (FAD) cases. The exact cellular function of PS1 is not known. To date …

Mutations in the presenilin-1 (PS-1) gene are one cause of familial Alzheimer's disease
(FAD). However, the functions of the PS-1 protein as well as how PS-1 mutations cause FAD …

Abstract Mutations in presenilin 1 (PS1) are linked to early onset of familial Alzheimer's
disease (FAD) and are shown to foster production of Aβ1–42/43 in FAD patients and …

Presenilin-1 (PS-1) gene mutations are responsible for the majority of the early onset familial
forms of Alzheimer disease (AD). Neither PS-1's anatomic distribution in brain nor …

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1 …

Early‐onset aggressive forms of Alzheimer's disease (AD) are of genetic nature and have
been linked to inherited mutations located on chromosomes 21, 14, and 1. The gene …

Dominantly inherited mutations in the genes encoding presenilins (PS) and the amyloid
precursor protein (APP) are the major causes of familial Alzheimer's disease (AD). The …

Thirty-seven missense mutations and a splice-site mutation in the presenilin gene PS1 on
chromosome 14 and two missense mutations PS2 on chromosome 1 co-segregate with …

Presenilin-2 (PS2) is one of three genes [amyloid precursor protein (APP), presenilin-1
(PS1) and PS2] shown to cause familial Alzheimer's disease (FAD), and is highly …