Amyloid beta (Aβ) peptides derived from proteolytic cleavage of amyloid precursor protein
(APP) are thought to be a pivotal toxic species in the pathogenesis of Alzheimer's disease …

Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

Alzheimer's disease (AD) is thought by many to result from the accumulation of the
neurotoxic amyloid‐β (Aβ) peptide in brain parenchyma. The process by which Aβ is …

J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …

Accumulating evidence suggests that dysregulated levels of amyloid β-protein precursor
(APP) and its catabolites contribute to the impaired synaptic plasticity and seizure incidence …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Because of the central place of amyloid in the histopathology of Alzheimer's disease (AD*),
current research seeks to determine the proteolytic mechanisms involved in the processing …

Abstract Alzheimer's disease (AD), which is predicted to affect 1 in 85 persons worldwide by
2050, results in progressive loss of neuronal functions, leading to impairments in memory …

Aβ peptides, the major components of Alzheimer's disease (AD) amyloid deposits, are
released following sequential cleavages by secretases of its precursor named the amyloid …

The amyloid precursor protein (APP) has occupied a central position in Alzheimer's disease
(AD) pathophysiology, in large part due to the seminal role of amyloid-β peptide (Aβ), a …