αβ T cell receptors (TCRs) have traditionally been viewed as receptors for peptide antigens
presented by either Major Histocompatibility Complex (MHC) class I (for CD8 T cells) or …

Human and mouse type I natural killer T (NKT) cells respond to a variety of CD1d-restricted
glycolipid antigens (Ags), with their NKT cell antigen receptors (NKT TCRs) exhibiting …

Little is known regarding the basis for selection of the semi-invariant αβ T cell receptor (TCR)
expressed by natural killer T (NKT) cells or how this mediates recognition of CD1d …

CD1d-restricted NKT cells use structurally conserved TCRs and recognize both self and
foreign glycolipids, but the TCR features that determine these Ag specificities remain …

Abstract Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell
receptor (TCR) and CD1d-antigen complex. However, the diversity of the NKT cell repertoire …

The CD1 family is a large cluster of non-polymorphic, major histocompatibility complex
(MHC) class-I-like molecules that bind distinct lipid-based antigens that are recognized by T …

Natural killer T cell antigen receptors (NKT TCRs) recognize lipid-based antigens (Ags)
presented by CD1d. Although the TCR α-chain is invariant, NKT TCR Vβ exhibits greater …

Together with peptides, T lymphocytes respond to hydrophobic molecules, mostly lipids,
presented by the non‐classical CD 1 family (CD 1a–e). These molecules have evolved …

The semi-invariant natural killer T cell receptor (NKT TCR) recognizes CD1d-lipid antigens.
Although the TCRα chain is typically invariant, the β chain expression is more diverse …

Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid
antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen …