Control of cryptic transcription in eukaryotes
M Rougemaille, D Libri - RNA Exosome, 2010 - Springer
Over the last few years, the development of large-scale technologies has radically modified
our conception of genome-wide transcriptional control by unveiling an unexpected high …
our conception of genome-wide transcriptional control by unveiling an unexpected high …
[HTML][HTML] Nuclear RNA exosome and pervasive transcription: dual sculptors of genome function
K Ogami, HI Suzuki - International journal of molecular sciences, 2021 - mdpi.com
The genome is pervasively transcribed across various species, yielding numerous non-
coding RNAs. As a counterbalance for pervasive transcription, various organisms have a …
coding RNAs. As a counterbalance for pervasive transcription, various organisms have a …
Exosome complex and pervasive transcription in eukaryotic genomes
D Belostotsky - Current Opinion in Cell Biology, 2009 - Elsevier
Exosome complex is widely conserved, functionally versatile, and essential constituent of
the machinery regulating gene expression in the nucleus as well as in the cytoplasm. While …
the machinery regulating gene expression in the nucleus as well as in the cytoplasm. While …
The RNA exosome contributes to gene expression regulation during stem cell differentiation
M Lloret-Llinares, E Karadoulama, Y Chen… - Nucleic Acids …, 2018 - academic.oup.com
Gene expression programs change during cellular transitions. It is well established that a
network of transcription factors and chromatin modifiers regulate RNA levels during …
network of transcription factors and chromatin modifiers regulate RNA levels during …
The RNA exosome shapes the expression of key protein-coding genes
M Wu, E Karadoulama, M Lloret-Llinares… - Nucleic acids …, 2020 - academic.oup.com
The ribonucleolytic exosome complex is central for nuclear RNA degradation, primarily
targeting non-coding RNAs. Still, the nuclear exosome could have protein-coding (pc) gene …
targeting non-coding RNAs. Still, the nuclear exosome could have protein-coding (pc) gene …
The RNA exosome promotes transcription termination of backtracked RNA polymerase II
JF Lemay, M Larochelle, S Marguerat… - Nature structural & …, 2014 - nature.com
The exosome is an RNA-decay complex that constantly monitors transcription and
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …
Post-transcriptional control of cellular differentiation by the RNA exosome complex
I Fraga de Andrade, C Mehta… - Nucleic acids …, 2020 - academic.oup.com
Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling
intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory …
intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory …
The regulation and functions of the nuclear RNA exosome complex
The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
The exosome and heterochromatin: multilevel regulation of gene silencing
S Coy, L Vasiljeva - RNA Exosome, 2010 - Springer
Heterochromatic silencing is important for repressing gene expression, protecting cells
against viral invasion, maintaining DNA integrity and for proper chromosome segregation …
against viral invasion, maintaining DNA integrity and for proper chromosome segregation …
The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteins
V Hessle, P Björk, M Sokolowski… - Molecular biology of …, 2009 - Am Soc Cell Biol
Eukaryotic cells have evolved quality control mechanisms to degrade aberrant mRNA
molecules and prevent the synthesis of defective proteins that could be deleterious for the …
molecules and prevent the synthesis of defective proteins that could be deleterious for the …