Over the last few years, the development of large-scale technologies has radically modified
our conception of genome-wide transcriptional control by unveiling an unexpected high …

The genome is pervasively transcribed across various species, yielding numerous non-
coding RNAs. As a counterbalance for pervasive transcription, various organisms have a …

Exosome complex is widely conserved, functionally versatile, and essential constituent of
the machinery regulating gene expression in the nucleus as well as in the cytoplasm. While …

Gene expression programs change during cellular transitions. It is well established that a
network of transcription factors and chromatin modifiers regulate RNA levels during …

The ribonucleolytic exosome complex is central for nuclear RNA degradation, primarily
targeting non-coding RNAs. Still, the nuclear exosome could have protein-coding (pc) gene …

The exosome is an RNA-decay complex that constantly monitors transcription and
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …

Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling
intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Heterochromatic silencing is important for repressing gene expression, protecting cells
against viral invasion, maintaining DNA integrity and for proper chromosome segregation …

Eukaryotic cells have evolved quality control mechanisms to degrade aberrant mRNA
molecules and prevent the synthesis of defective proteins that could be deleterious for the …