Hypermineralized tissues related to enamel are identified in early vertebrates, 450 millions
years ago (Ma). The enamel matrix proteins (EMPs), amelogenin (AMEL), ameloblastin …

Abstract Background/Aims: Enamel and enameloid were identified in early jawless
vertebrates, about 500 million years ago (MYA). This suggests that enamel matrix proteins …

Amelogenin plays a crucial role in enamel structure and mineralization, but the function of its
various domains is far to be understood. Evolutionary analysis seems to be a promising way …

The amelogenin gene contributes the majority of tooth enamel proteins and plays a
significant role in enamel biomineralization. While several mammalian and reptilian …

The three major enamel matrix proteins (EMPs): amelogenin (AMEL), ameloblastin (AMBN),
and enamelin (ENAM), are intrinsically linked to tooth development in tetrapods. However …

Amelogenin gene organization varies from 6 exons (1, 2, 3, 5, 6, 7) in amphibians and
sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and “4b”, the latter being …

Amelogenins are the major proteins involved in tooth enamel formation. In the present study,
we have cloned and sequenced four novel amelogenins from three amphibian species in …

As the major enamel matrix protein contributing to tooth development, amelogenin has been
demonstrated to play a crucial role in tooth enamel formation. Previous studies have …

Enamelin (ENAM) has been shown to be a crucial protein for enamel formation and
mineralization. Previous molecular analyses have indicated a probable origin early in …

Background In a recent study, we have demonstrated that amelotin (AMTN) gene structure
and its expression during amelogenesis have changed during tetrapod evolution. Indeed …