Prophylactic eculizumab after renal transplantation in atypical hemolytic–uremic syndrome

LB Zimmerhackl, J Hofer, G Cortina… - … England Journal of …, 2010 - Mass Medical Soc
To the Editor: Atypical hemolytic–uremic syndrome is a rare microangiopathic hemolytic
condition characterized by thrombocytopenia and acute renal failure. 1 The prognosis for …

Eculizumab for congenital atypical hemolytic–uremic syndrome

RA Gruppo, RP Rother - New England Journal of Medicine, 2009 - Mass Medical Soc
To the Editor: Atypical hemolytic–uremic syndrome of infancy is a rare disorder that is
associated with thrombotic microangiopathy and acute renal failure. It often involves …

Eculizumab for atypical hemolytic–uremic syndrome

J Nürnberger, T Philipp, O Witzke… - … England Journal of …, 2009 - Mass Medical Soc
To the Editor: Atypical hemolytic–uremic syndrome is a disease of uncontrolled complement
activation associated with a high mortality rate, and most cases progress to end-stage renal …

Successful treatment of the postpartum atypical hemolytic uremic syndrome with eculizumab

S Zschiedrich, EP Prager, EW Kuehn - Annals of internal medicine, 2013 - acpjournals.org
Background: Thrombocytopenia with intravascular hemolysis is a serious complication of
pregnancy. When it occurs in the second and third trimesters, it is usually associated with …

Discontinuation of eculizumab maintenance treatment for atypical hemolytic uremic syndrome

JFM Wetzels, NCAJ van de Kar - American Journal of Kidney Diseases, 2015 - ajkd.org
Dr Ardissino and colleagues 1 report successful discontinuation of eculizumab treatment in
7 of 10 patients with atypical hemolytic uremic syndrome (aHUS). This important report …

Safety and long-term efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic–uremic syndrome

V Chatelet, V Frémeaux-Bacchi… - American Journal of …, 2009 - amjtransplant.org
Atypical HUS develops as the result of unregulated complement progression and has been
shown to cause microangiopathic hemolytic anemia. Plasmapheresis is currently used in an …

Atypical hemolytic uremic syndrome: from the rediscovery of complement to targeted therapy

F Fakhouri, V Frémeaux-Bacchi, C Loirat - European Journal of Internal …, 2013 - Elsevier
Atypical hemolytic uremic syndrome (aHUS) is a devastating form of renal thrombotic
microangiopathy. In the last five years, we have finally witnessed a dramatic improvement in …

Efficacy of eculizumab in a patient with factor-H-associated atypical hemolytic uremic syndrome

AL Lapeyraque, V Frémeaux-Bacchi, P Robitaille - Pediatric nephrology, 2011 - Springer
Atypical hemolytic uremic syndrome (aHUS) is a rare, chronic, life-threatening disease due
to complement dysregulation. The use of early-onset plasma therapy is recommended, but …

Eculizumab cessation in atypical hemolytic uremic syndrome

SA Merrill, ZD Brittingham, X Yuan… - Blood, The Journal …, 2017 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is a complementmediated thrombotic
microangiopathy (TMA) characterized by mechanical hemolysis, renal impairment …

Gastrointestinal angiodysplasia and aortic stenosis

TE Warkentin, JC Moore… - New England Journal of …, 2002 - Mass Medical Soc
To the Editor: For unknown reasons, bleeding from gastrointestinal angiodysplasia in
patients with severe aortic stenosis (Heyde's syndrome1) usually ceases after aortic-valve …