Despite the extensive effort over several decades searching for new pharmacological tools
for clinical pain treatment, opioid analgesics remain the mainstay of contemporary pain …

Opioids have become the unequivocal therapy of choice in treating many varieties of chronic
pain. With the increased prescription of opioids, some unintended consequences have …

There is a curious and paradoxic phenomenon, reliably demonstrated in animal models, that
consists of an increased sensitivity to pain that is apparently induced by the very opioid …

Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although
common concerns regarding the use of opioids include the potential for detrimental side …

While opioids remain a valid and effective analgesic strategy for patients suffering from a
wide variety of painful conditions, they are not a panacea. Increasingly, physicians must …

Opioids are the drugs of choice for the treatment of moderate to severe acute and chronic
pain. However, clinical evidence suggests that–besides their well-known analgesic activity …

Opioids are a widely used pharmacological therapy for moderate-to-severe pain. Their use
in the management of chronic non-cancer pain has escalated in recent years, particularly in …

Opioid-induced hyperalgesia (OIH) is a paradoxical effect of opioids that is not consensually
recognized in clinical settings. We conducted a revision of clinical and preclinical studies …

Opioid analgesics have become a cornerstone in the treatment of moderate to severe pain,
resulting in a steady rise of opioid prescriptions. Subsequently, there has been a striking …

INTRODUCTION It is well recognized that opioids are the analgesics of choice for the
treatment of moderate to severe pain. However, a large number of clinical studies have …