[PDF][PDF] Molecular characterization of tumor vascular phenotype and pharmacology of antiangiogenic therapy
E Langenkamp - 2010 - research.rug.nl
Microvascular endothelial cells display a large degree of heterogeneity in function
depending on their location in the vascular tree. The existence of organ-specific …
depending on their location in the vascular tree. The existence of organ-specific …
Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer
E Langenkamp, G Molema - Cell and tissue research, 2009 - Springer
Microvascular endothelial cells display a large degree of heterogeneity in function
depending on their location in the vascular tree. The existence of organ-specific …
depending on their location in the vascular tree. The existence of organ-specific …
Role of the tumor microenvironment in mediating response to anti-angiogenic therapy
YD Jung, SA Ahmad, Y Akagi, Y Takahashi… - Cancer and Metastasis …, 2000 - Springer
Despite the development of innovative anti-angiogenic strategies, early clinical trials have
not replicated the results observed from preclinical models. One reason for this apparent …
not replicated the results observed from preclinical models. One reason for this apparent …
Exploring the role of endothelium in the tumour response to anti-angiogenic therapy
A chronic hyperactivated angiogenic state in cancer plays an important role in tumour
growth and metastasis and has been identified as one of the hallmarks of cancer. Inhibition …
growth and metastasis and has been identified as one of the hallmarks of cancer. Inhibition …
Molecular phenotypes of endothelial cells in malignant tumors
Angiogenesis is an essential process for tumor growth, progression, and metastasis, and it is
one of the hallmarks of cancer. In addition to being structurally atypical, tumor blood vessels …
one of the hallmarks of cancer. In addition to being structurally atypical, tumor blood vessels …
Introduction: How tumor-endothelial cell communication within the tumor microenvironment affects angiogenesis
L Morbidelli, S Donnini - … Drugs as Chemosensitizers in Cancer Therapy, 2022 - Elsevier
Angiogenesis, the formation of new blood vessels from preexisting ones, occurs when the
high proliferation rate of cancer cells creates hypoxic zones in the tumor mass and …
high proliferation rate of cancer cells creates hypoxic zones in the tumor mass and …
Tumor endothelial cells are targets for selective therapies: in vitro and in vivo models to evaluate antiangiogenic strategies
A Dutour, M Rigaud - Anticancer research, 2005 - ar.iiarjournals.org
Angiogenesis is a complicated process, essential for tumor progression and metastasis.
Extensive work has been done to understand the mechanisms of tumor angiogenesis and …
Extensive work has been done to understand the mechanisms of tumor angiogenesis and …
Advantages of targeting tumor angiogenesis in cancer treatment
O Feron - Trends in Pharmacological Sciences, 2004 - infona.pl
The fact that a single blood vessel can support the life of thousands of tumor cells has been
known for a long time. However, therapeutic strategies that aim to impair vascular …
known for a long time. However, therapeutic strategies that aim to impair vascular …
Opportunities and challenges in tumor angiogenesis research: back and forth between bench and bed
L Qin, JL Bromberg-White, CN Qian - Advances in cancer research, 2012 - Elsevier
Angiogenesis is essential for tumor growth and metastasis. Many signaling pathways are
involved in regulating tumor angiogenesis, with the vascular endothelial growth factor …
involved in regulating tumor angiogenesis, with the vascular endothelial growth factor …
Oncogenes and tumor angiogenesis: the question of vascular 'supply'and vascular 'demand'
J Rak, LY Joanne - Seminars in cancer biology, 2004 - Elsevier
Among novel promising approaches that have recently entered the scene of anti-cancer
therapy angiogenesis inhibition and targeting cancer-causing genes (eg oncogenes) are of …
therapy angiogenesis inhibition and targeting cancer-causing genes (eg oncogenes) are of …