Abstract p66Shc, a 66 kDa proto-oncogene Src homologous-collagen homologue (Shc)
adaptor protein, is classically known in mediating receptor tyrosine kinase signaling and …

Background p66Shc, an isoform of Shc adaptor proteins, mediates diverse signals, including
cellular stress and mouse longevity. p66Shc protein level is elevated in several carcinomas …

Abstract p66Shc is shown to negatively regulate the life span in mice through reactive
oxygen species (ROS) production. Recent reports, however, revealed that p66Shc protein …

Steroid hormones exhibit diverse biological activities. Despite intensive studies on steroid
function at the genomic level, their nongenomic actions remain an enigma. In this study, we …

Abstract p66Shc, a member of the ShcA (Src homologous-collagen homologue) adaptor
protein family, is one of the three isoforms of this family along with p46Shc and p52Shc …

p66Shc functions as a longevity protein in murine and exhibits oxidase activity in regulating
diverse biological activities. In this study, we investigated the role of p66Shc protein in …

The adaptor protein p66Shc links membrane receptors to intracellular signalling pathways
and has the potential to respond to energy status changes and regulate mitogenic …

Metastatic castration-resistant (CR) prostate cancer (PCa) is a lethal disease for which no
effective treatment is currently available. p66Shc is an oxidase previously shown to promote …

Prostate cancer (PCa) remains the second leading cause of cancer-related deaths in US
men due to the development of the castration-resistant (CR) PCa phenotype. A useful cell …

p66Shc was the first mammalian gene whose mutation was demonstrated to increase
resistance to oxidative stress and to prolong life span. Many hypotheses have been …