Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells.
Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP …

Macroautophagy (autophagy) is a lysosomal degradation pathway that is conserved from
yeast to humans that plays an important role in recycling cellular constituents in all cells. A …

Spontaneous Ca2+ signaling from the InsP3R intracellular Ca2+ release channel to
mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP …

A rise in cytosolic Ca 2+ concentration is used as a key activation signal in virtually all
animal cells, where it triggers a range of responses including neurotransmitter release …

The role of intracellular Ca2+ signaling in starvation-induced autophagy remains unclear.
Here, we examined Ca2+ dynamics during starvation-induced autophagy and the …

The endoplasmic reticulum (ER) and mitochondria form tight functional contacts that
regulate several key cellular processes. The formation of these contacts involves “tethering …

Autophagy is essential for maintaining glucose homeostasis, but the mechanism by which
energy deprivation activates autophagy is not fully understood. We show that Mec1/ATR, a …

Autophagy is an important cell-biological process responsible for the disposal of long-lived
proteins, protein aggregates, defective organelles and intracellular pathogens. It is activated …

In eukaryotic cells, activation of cell surface receptors that couple to the phosphoinositide
pathway evokes a biphasic increase in intracellular free Ca 2+ concentration: an initial …

Pluripotent stem cells, including induced pluripotent and embryonic stem cells (ESCs), have
less developed mitochondria than somatic cells and, therefore, rely more heavily on …