In eukaryotic cells, the transcription of genes is accurately orchestrated both spatially and
temporally by the C-terminal domain of RNA polymerase II (CTD). The CTD provides a …

At the onset of transcription, many protein machineries interpret the cellular signals that
regulate gene expression. These complex signals are mostly transmitted to the …

The highly conserved C-terminal domain (CTD) of the largest subunit of RNA polymerase II
comprises a consensus heptad (Y 1 S 2 P 3 T 4 S 5 P 6 S 7) repeated multiple times …

Abstract Background Eukaryotic RNA polymerase II contains a C-terminal repeated domain
(CTD) consisting of 52 consensus heptad repeats of Y 1 S 2 P 3 T 4 S 5 P 6 S 7 that mediate …

The phosphorylation states of RNA polymerase II coordinate the process of eukaryotic
transcription by recruitment of transcription regulators. The individual residues of the …

The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-
terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of …

The C-terminal domain (CTD) of the largest subunit of RNA polymerase II provides an
anchoring point for a wide variety of proteins involved in mRNA synthesis and processing …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

The epigenetic phenomenon is known to derive the phenotypic variation of an organism
through an interconnected cellular network of histone modifications, DNA methylation and …