Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads

GE Bentley, K Tsutsui, LJ Kriegsfeld - Brain research, 2010 - Elsevier
The hypothalamo-pituitary-gonadal (HPG) axis integrates internal and external cues via a
balance of stimulatory and inhibitory neurochemical systems to time reproductive activity …

[HTML][HTML] Contribution of GnIH research to the progress of reproductive neuroendocrinology

K Tsutsui, T Ubuka, YL Son, GE Bentley… - Frontiers in …, 2015 - frontiersin.org
Since the discovery of gonadotropin-releasing hormone (GnRH) in mammals at the
beginning of the 1970s, it was generally accepted that GnRH is the only hypothalamic …

Gonadotropin-inhibitory hormone (GnIH): discovery, progress and prospect

K Tsutsui, T Ubuka, GE Bentley, LJ Kriegsfeld - General and comparative …, 2012 - Elsevier
A hypothalamic neuropeptide, gonadotropin-releasing hormone (GnRH), is the primary
factor regulating gonadotropin secretion. An inhibitory hypothalamic neuropeptide for …

A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH): Biosynthesis, mode of action and functional significance

K Tsutsui - Progress in neurobiology, 2009 - Elsevier
Identification of novel neurohormones that play important roles in the regulation of pituitary
function is essential for the progress of neurobiology. The decapeptide gonadotropin …

Gonadotrophin‐inhibitory hormone: a multifunctional neuropeptide

GE Bentley, T Ubuka, NL McGuire… - Journal of …, 2009 - Wiley Online Library
Gonadotrophin‐inhibitory hormone (GnIH) was discovered 8 years ago in birds. Its
identification raised the possibility that gonadotrophin‐releasing hormone (GnRH) is not the …

Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function

K Tsutsui, GE Bentley, G Bedecarrats, T Osugi… - Frontiers in …, 2010 - Elsevier
Identification of novel neurohormones that regulate the reproductive axis is essential for the
progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) …

Reproductive neuroendocrinology of mammalian gonadotropin‐inhibitory hormone

T Ubuka, K Tsutsui - Reproductive Medicine and Biology, 2019 - Wiley Online Library
Abstract Background Gonadotropin‐inhibitory hormone (GnIH) was discovered in the
Japanese quail brain in 2000 as a hypothalamic neuropeptide that suppresses luteinizing …

Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior

K Tsutsui, T Ubuka, K Ukena - Frontiers in Neuroendocrinology, 2022 - Elsevier
The discovery of gonadotropin-inhibitory hormone (GnIH) in 2000 has led to a new research
era of reproductive neuroendocrinology because, for a long time, researchers believed that …

Breakthrough in neuroendocrinology by discovering novel neuropeptides and neurosteroids: 1. Discovery of gonadotropin-inhibitory hormone (GnIH) across …

K Tsutsui, T Ubuka - General and Comparative Endocrinology, 2014 - Elsevier
Bargmann–Scharrer's discovery of “neurosecretion” in the first half of the 20th century has
since matured into the scientific discipline of neuroendocrinology. Identification of novel …

Gonadotropin-inhibitory hormone

K Tsutsui, T Ubuka - Handbook of Hormones, 2016 - Elsevier
Gonadotropin-inhibitory hormone (GnIH) was originally identified in birds, and subsequently
in mammals and other vertebrates. GnIH acts on the pituitary and on gonadotropin-releasing …